Ansonica is one of the principal native Sicilian white varietes. It is cultivate primarily in the provinces of Trapani, Palermo and Agrigento. In particular, the primary aromas of this variety give the wines unmistakable personality. The Ansonica produced by Donnafugata at Contessa Entellina displays great refinement due to rationalization of the techniques of cultivation employed in securing the best balance between the variety's vegetation and production.

Nero d’Avola is the most rapresentative cultivar in the panorama of Sicily's native varietes. Since a viticulture primarly oriented to quality has substantialy reduced yields per vine, Nero d'Avola has become an attractive variety. And it could attract even more interest because of scientific research focused on clonal selection. Currently, no clones of Nero d'Avola have been identified, althought many "populations" are recognized. One of them has been discovered in the Contessa Entellina district by Donnafugata's technical staff. The estate is selecting vines from among that "population", which is regarded as responding best to Donnafugata's quality requirements, for the planting of the new vineyards.

Zibibbo (Moscato d’Alessandria) is derived from the Arabic word zibibb, meaning raisin. The Arabs brought this variety to Pantelleria from the North African coast hundreds of years ago. Zibibbo, trained in the alberello (head-trained bush) system, thrives in the hot, dry and windy climate of this island of volcanic origin. Those conditions are ideal for the concentration of the grape's unequaled wealth of sugars and olfactory nuances.